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Thiourea, hydrazone, thiosemicarbazone, succinamic acid and pyrazolone analogs in hunting of potential therapeutics farzana naz by: farzana naz bodied type: text issue details: karachi; hej research institute of chemistry, international centrist for chemical and biological sciences, university of karachi; 2012 description: phd thesis, available in black and white and electronic formats, supervised.
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Is it safe to take thiosemicarbazone or isoniazid?
In common with isoniazid, thiacetazone (acetylaminobenzaldehyde thiosemicarbazone) inhibits the synthesis of mycolic acid, but by a poorly understood mechanism. Due to its very high incidence of severe, sometimes fatal, skin reactions – exfoliative dermatitis and Stevens–Johnson syndrome – thiacetazone should no longer be used.
Which is more active pyrrole-2 carbaldehyde or thiosemicarbazone?
The copper complex of the thiosemicarbazone of pyrrole-2-carbaldehyde shows a broad-spectrum antibacterial activity inhibiting the growth of a range of Gram-positive bacteria and fungi at concentrations of 12–50 μg ml −1, whereas the nickel and cobalt complexes are only moderately active .
Are there any new derivatives of thiosemicarbazone?
All the derivatives of thiosemicarbazones and their metal chelates have been descripted, which were explored by researchers in last 5 years. The coordination compounds were disclosed with respect to their bonding with metal ions and geometry.
Why are thiosemicarbazones an important class of ligands?
Thiosemicarbazones (TSCs) have turned out as an important class of N, S-donor ligands over a span of time due to their variable donor properties, structural diversity and biological applications. This review gives a detailed account in words of synthesis and applications of thiosemicarbazones and their metal coordinates reported recently.
Last Update: Oct 2021
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